Subtitle: Following the Science
The scientific research on the Endocannabinoid System (ECS) is starting to erupt. Some of the most recent research out of Oregon State Pharmacy School points to the ECS showing that the different acid forms in the phytocannabinoid plant (Cannabis sativa L) can and do have an impact on the coronavirus ability to penetrate the body.
Several acid forms of cannabinoids show that the spike protein of the coronavirus can be blocked, thereby limiting ACE2 receptor in the body from being invaded by this virus.
I’m putting my anecdotal analysis to this recent scientific research because I have observed that my clientele taking the cannabinoid CBD as a daily supplement have mitigated the intervention of them experiencing COVID-19 signs or symptoms. These new research articles and subsequent news release via cable TV has put a spotlight on the acid forms of the cannabinoids in the Cannabis sativa plant.
In a lecture several years ago, Dr. Rafael Missoula, The Godfather of Cannabis, talked about not forgetting about the importance of the acid forms of Cannabinoids, CBG-A, CBD-A, etc., versus the neutral forms of the cannabinoid, known as CBG, CBD. etc. which has had the most public attention.
Dr. Rafael Missoula made this point about the acid form of Cannabinoids having an important intervention within our physiological make-up. It was his plea for the medical community not to take 30 more years for the scientific world to understand the importance of the acid forms of cannabinoids.
I took this message to heart, and utilized a mechanism known as ultrasonic cavitation to avoid solvents and heat from driving the chemical reaction from the acid form to the neutral form, causing a decarboxylation of the product. In doing so, I was able to get a much higher level of CBD-A and put it together with the CBD and now had two different pathways to attacking free radicals, oxidative stress and information.
Now follow the Science!
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe
acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2. ACE2 receptor.are widely expressed in the body, including, in the lungs, cardiovascular system, gut, kidneys, central nervous system, and adipose tissue. ACE2 receptors have been identified as the SARS-
CoV-2 receptor, the infective agent responsible for coronavirus disease 2019 (COVID-19), providing a critical link between immunity, inflammation, ACE2, and cardiovascular disease.
Studying the acid form from the different cannabinoids, I discovered that the acid form of CBD (CBD- A) does not work via the Endocannabinoid Pathway (ECP) but works through the Cyclooxygenase Pathway (COG). This COG pathway is commonly used in the pharmaceutical production of anti- inflammatory medications such as Motrin, Aleve, etc.
So, here was another pathway which we could use to fight inflammation and free radicals. But what became even more relevant is the fact that CBD- A has a great affinity for serotonin receptors. This was major because the presence of serotonin has a great deal to do with people’s moods, and the basis for different drugs that act as an agonist for serotonin maintenance in the body.
2PATH therefore works through two mechanisms: Mechanism one, CBD-A works through the Cyclooxygenase Pathway with a high-grade special affinity for serotonin and the second mechanism, the neutral form CBD works through the ECP with CBD. With the advent of these new research articles, CBG-A another acid form can now be added to the therapeutic mix.
2PATH + is born. With my continuous appreciation for the acid forms, I added this acid form of a cannabinoid known as CBG-A to the mix. The acid form CBG-A is the stem cell for the formulations of the other cannabinoids and can also be preserved if we do not use solvents and heat which usually drives reaction to its neutral form, CBG
This is not to downgrade CBG by any stretch of the imagination. Recent articles have pointed to CBG as a possible treatment for prostate cancer. More on that later. What is important now is that I want to introduce you to 2PATH +.
2PATH+ is a Formulation that has two acid forms, CPG-A and CBD-A along with the neutral form, CBD. The CoA testing bears out the concentrations of the cannabinoids and 2PATH + will be available in our Shopify online store very soon. Visit http://www.dailyvitaminCBD.com and get your “Daily Dose of Wellness”.
Eric I. Mitchell, MD FACPE
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