Munchies without THC


Munchies are often a hallmark and associated with THC inhalation (smoking a joint). This can be true if you inhale medical cannabis. However, the munchies can also be traced to our homeostatic neurotransmission system known as the Endocannabinoid System (ECS) without any external cannabis induction (smoking that joint).


The munchies are being controlled by the same system, the ECS. But, in this case of the munches, it is being impacted by a natural occurring Cannabinoid called 2-AG. In this case, our bodies create this known Cannabinoid which our body’s make. Do not get hung up on 2- arachidonoylglycerol (2-AG) just stay with me on the munchies. The pathophysiology of 2-AG is another blog for another time!


It has been well-established that the ECS role in moderating food intake is a valued function of this ECS system. In fact, numerous animal studies have shown a significant relationship between our 2-AG that our bodies make and the munchies.


Animal models have also shown that by manipulating the levels of 2-AG, by turning on or off the enzymes responsible for its production and degradation, can be therapeutic. Yes, scientists are very interested in how the ECS, and 2-AG specifically, is involved in the development of certain neurologic diseases. Scientists may be able to improve clinical outcomes of different neurological diseases.


2-AG has now been found to serve as a reserve of an important fatty acid in the body called arachidonic acid (AA). Common anti-inflammatory medications like ibuprofen (Advil), naproxen (Aleve), and acetaminophen (Tylenol) all target parts of the AA cascade. With a custom formulation of CBD and CBD-A, I have formulated what is called 2PATH™. 2PATH ™also serves and plays some of the same rule as a powerful anti-inflammatory when taken as an external source (2Path™).


AG is essential to maintaining homeostasis (balance) in the body. It does this in many complex ways, but similar to THC and anandamide, most of 2-AG’s actions are mediated through actions at the CB1 and CB2 receptors. Its abundance suggests that 2-AG is one of the most important endocannabinoids, regulating numerous important processes throughout the body.


Authored by
Eric I. Mitchell, MD FACPE

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